If you're showing off a weapon for example, we don't need to see other NPCs. Don't forget the make the subject stand out (lightning is important in this case), and to crop the picture.PNG files would ideally be optimized (use PNGGauntlet), although it is not necessary. Consider the compression of the image you have taken.Use a scree capture software ( Gadwin, FRAPS) instead. Note that screenshots taken from the game will generally not be uploaded correctly (it may come back as a 'blank' image) and may not be the quality you wish.Make sure you have the highest graphical settings possible everything.
You will probably want to try out different angles and zoom before selecting your final picture.